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Application Examples and Notes

  1. Flash column comparison with ISCO RF columns.pdf    (Document in English)
  2. Flash column comparison with RF and Gold columns by Client.pdf    (Document in English)
  3. SuperSep reversed phase C18 flash columns.pdf    (Document in English)
  4. Luknova flash column comparison with other competitors columns.pdf    (Document in English)
  5. How to pack Luknova empty flash columns.pdf    (Document in English)

News

  1. Integrated polymer filter patent was granted on November 18, 2015.

  2. Prof. Martin D. Burke's research team at Howard Hughes Medical Institute (HHMI), Department of Chemistry, University of Illinois at Urbana-Champaign, published a leading research article on Science  13 Mar 2015:Vol. 347, Issue 6227, pp. 1221-1226. The article "Synthesis of many different types of organic small molecules using one automated process" reported a broadly applicable automated process and illuminated an actionable roadmap to a more general and automated approach for small-molecule synthesis.  Article link and Supplementary Materials link in PDF (free Document in English).  Luknova flash columns products were employed to support this leading research.

  3. Luknova liquid chromatographic column patent was granted on August 25, 2015.

  4. Luknova liquid chromatographic column patent was granted on April 27, 2010.

  5. Luknova liquid chromatographic column patent was granted on December 23, 2009. 

 

Selected Publications

  1. Further insight into the asymmetric vinylogous Mukaiyama aldol reaction (VMAR); application to the synthesis of the C27–C45 segment of lagunamide A, Brent A. Banasik, Lee Wang, Arielle Kanner, B. Mikael Bergdahl, Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA, Tetrahedron, Volume 72, Issue 19, 12 May 2016, Pages 2481–2490.  Article link.

  2. 2,2,2-Trifluoroethyl Oxalates in the One-Pot Parallel Synthesis of Hindered Aliphatic Oxamides†,Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Sergey E. Pipko, Alexander V. Grishchenko, Anton V. Zhemera, Anzhelika I. Konovets, Roman A. Doroschuk, Yurii V. Dmytriv, Olga A. Zaporozhets and Andrey Tolmachev, European Journal of Organic Chemistry, Volume 2016, Issue 12, pages 2120–2130, April 2016.   Article link.

  3. Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s), Pushkar M. Kulkarni‡, Abhijit R. Kulkarni‡, Anisha Korde‡∥, Ritesh B. Tichkule∥#, Robert B. Laprairie$, Eileen M. Denovan-Wright$, Han Zhou∥#, David R. Janero‡∥, Nikolai Zvonok∥, Alexandros Makriyannis‡∥#, Maria G. Cascio§, Roger G. Pertwee§, and Ganesh A. Thakur*‡; ‡Department of Pharmaceutical Sciences, Bouvé College of Pharmacy, ∥Center for Drug Discovery, and #Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States; $ Department of Pharmacology, Dalhousie University, Halifax NS Canada B3H 4R2; School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland;  J. Med. Chem., 2016, 59 (1), pp 44–60.   Article link.

  4. Separation of [99mTc]pertechnetate and molybdate using polyethylene glycol coated C18 and C30 resins, J.D. Anderssona, , , J.S. Wilsonb, J.A. Romaniuka, A.J.B. McEwanb, D.N. Abramsa, S.A. McQuarriea, K. Gagnona; a- University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada; b- Edmonton PET Centre, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada; Applied Radiation and Isotopes, Volume 110, April 2016, Pages 193–199.  Article link.

  5. Synthesis of many different types of organic small molecules using one automated process, Junqi Li*, Steven G. Ballmer*, Eric P. Gillis, Seiko Fujii, Michael J. Schmidt, Andrea M. E. Palazzolo, Jonathan W. Lehmann, Greg F. Morehouse, Martin D. Burke†; Howard Hughes Medical Institute (HHMI), Department of chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Science  13 Mar 2015:Vol. 347, Issue 6227, pp. 1221-1226.  Article link and  Supplementary Materials link in PDF (free Document in English).
  6. One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones, Andrey V. Bogolubsky†, Yurii S. Moroz*†‡, Pavel K. Mykhailiuk*†§, Eugeniy N. Ostapchuk†‡, Alexander V. Rudnichenko†, Yurii V. Dmytriv†, Anna N. Bondar§, Olga A. Zaporozhets§, Sergey E. Pipko‡, Roman A. Doroschuk§, Liudmyla N. Babichenko†‡, Anzhelika I. Konovets†∥, and Andrey Tolmachev†‡; Enamine, Ltd., 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; ChemBioCenter, Kyiv National Taras Shevchenko University, 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; § Department of Chemistry, Kyiv National Taras Shevchenko University, 64 Volodymyrska Street, Kyiv, 01601, Ukraine; The Institute of High Technologies, Kyiv National Taras Shevchenko University, 4 Glushkov Street, Building 5, Kyiv, 03187, Ukraine. ACS Comb. Sci., 2015, 17 (6), pp 348–354.  Article link.

  7. 2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides, Andrey V. Bogolubsky†, Yurii S. Moroz*†‡, Pavel K. Mykhailiuk*†§, Sergey E. Pipko‡, Anton V. Zhemera†, Anzhelika I. Konovets†∥, Olena O. Stepaniuk†$, Inna S. Myronchuk†$, Yurii V. Dmytriv†, Roman A. Doroschuk§, Olga A. Zaporozhets§, and Andrey Tolmachev†‡; Enamine, Ltd., 78 Chervonotkatska Street, Kyiv, 02094, Ukraine; ChemBioCenter, Kyiv National Taras Shevchenko University, 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; § Department of Chemistry, Kyiv National Taras Shevchenko University, 64 Volodymyrska Street, Kyiv, 01601, Ukraine; The Institute of High Technologies, Kyiv National Taras Shevchenko University, 4 Glushkov Street, Building 5, Kyiv, 03187, Ukraine; $ National Technical University of Ukraine “Kyiv Politechnic Institute”, 37 Peremohy Avenue, Kyiv, 03056, Ukraine; ACS Comb. Sci., 2015, 17 (10), pp 615–622.  Article link.

  8. Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)–Arene Complex, Catherine M. Clavel†, Emilia Păunescu†, Patrycja Nowak-Sliwinska†, Arjan W. Griffioen‡, Rosario Scopelliti†, and Paul J. Dyson*†; Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland; Angiogenesis Laboratory, Department of Medical Oncology, VUMC Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands; J. Med. Chem., 2014, 57 (8), pp 3546–3558.  Article link.

  9. Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis, Anja Meissnera, Helena I. Boshoffb, Mahalakshmi Vasana, Benjamin P. Duckwortha, Clifton E. Barry IIIb, Courtney C. Aldricha, , a Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA; b Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Bioorganic & Medicinal Chemistry, Volume 21, Issue 21, 1 November 2013, Pages 6385–6397.  Article link.

  10. Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumanniiJoão Neres†, Curtis A. Engelhart†‡, Eric J. Drake§, Daniel J. Wilson†, Peng Fu†, Helena I. Boshoff∥, Clifton E. Barry3rd∥, Andrew M. Gulick§, and Courtney C. Aldrich*†; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, United States; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States; § Hauptman-Woodward Institute and Department of Structural Biology, University at Buffalo, Buffalo, New York 14203-1102, United States; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, United States; J. Med. Chem., 2013, 56 (6), pp 2385–2405.  Article link.

  11. Transformation of Pro-Leu-Gly-NH2 Peptidomimetic Positive Allosteric Modulators of the Dopamine D2 Receptor into Negative Modulators, Swapna Bhagwanth†, Satyendra Mishra†, Ritesh Daya‡, Jordan Mah‡, Ram K. Mishra‡, and Rodney L. Johnson*; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States; Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street W, Hamilton, Ontario L8N 3Z5, Canada.  ACS Chem. Neurosci., 2012, 3 (4), pp 274–284.  Article link.

  12. Application of chemoenzymatic hydrolysis in the synthesis of 2-monoacylglycerols, Kyle M. Whitten, Alexandros Makriyannis, Subramanian K. Vadivel; Center for Drug Discovery, 116 Mugar Hall, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, Unites States. Tetrahedron, Volume 68, Issues 27–28, 8 July 2012, Pages 5422–5428.  Article link.

  13. Coupling flash liquid chromatography with mass spectrometry for enrichment and isolation of milk oligosaccharides for functional studies, John S. Struma, Danielle Aldredgea, Daniela Barileb, Carlito B. Lebrillaa,c; a Department of Chemistry, University of California, Davis, Davis, CA 95616, USA; b Foods for Health Institute, Department of Food Science and Technology, University of California, Davis, Davis, CA 95616, USA; c Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95616, USA. Analytical Biochemistry, Volume 424, Issue 2, 15 May 2012, Pages 87–96.  Article link.
  14. Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosisAmol Gupte†, Helena I. Boshoff‡, Daniel J. Wilson†, João Neres†, Nicholas P. Labello†, Ravindranadh V. Somu†, Chengguo Xing§, Clifton E. BarryIII‡ and Courtney C. Aldrich*†; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, J. Med. Chem., 2008, 51 (23), pp 7495–7507.   Article link. 

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