SuperSep™ Flash Columns Overview

Luknova designs, manufactures, and supplies top quality and cost-effective prepacked and unpacked (empty) flash columns from normal phase, reversed phase, cation and anion exchange to mixed phase flash chromatography separation of various organic compounds.  These columns directly fit all the flash chromatography systems, including but not limited to ISCO CombiFlash®, Biotage Isolera™, Grace Reveleris®, Interchim PuriFlash®, and flash systems from Agilent and Yamazen et al.

 

 

  • Silica columns: standard silica at averaged 50 micron particle size and and high performance silica at 25 micron particle size.

  • Specialty phase columns: silica-based C18, Cyano, Diol, Amine, SAX, and SCX, and alumina (acid, neutral, and basic).

  • Empty flash column sets are available for your own packing as a cost-effective solution.

  • Bulk packing materials: silica, C18, and resin-based materials are available for scale up process and your own packing needs.

  • Dry loading columns: needle-shape and also fit solid phase extractions application.

  • Chromatography plots for flash purification examples, columns selection guide, and packing material physical and chemical properties are available.

  • Luknova Flash columns application in selected publications reported.

 

Click following tab to display product description and part numbers.

 

Silica columns

Silica columns are normal phase columns for flash purification of organic compounds with sample loading up to 10% of packed mass. Both standard and High Performance (HP) columns are packed with high purity silica gel with narrow particle size distribution and narrow pH range (6.8-7.2) and special mechanical packing technology enable significant advantages over leading competitors in purification efficiency, resolution, and column reproducibility. The columns are compatible with all purification systems.

 

Order Information for standard silica and high performance silica prepacked flash columns
Standard silica prepacked flash columns (40-60 μm)
Size P/N Qty/PK CV (ml) Flow Rate (ml/min) Sample Loading
4g FC003004 40 5 18 ± 5 4mg — 0.4g
FC003004-0 480
12g FC003012 30 17 30 ± 5 12mg — 1.2g
FC003012-0 360
25g FC003025 25 34 35 ± 10 25mg — 2.5g
FC003025-0 300
40g   FC003040 20 57 40 ± 15 40mg — 4.0g
FC003040-0 240
80g FC003080 10 120 60 ± 20 80mg — 8.0g
FC003080-0 80
120g FC003120 8 190 85 ± 20 0.12g — 12g
FC003120-0 64
240g FC003240 4 330 60 — 170 0.24g — 24g
FC003240-0 32 150 ± 20 for high pressure system
330g FC003330 4 450 80 — 220 0.33g — 33g
FC003330-0 32 200 ± 20 for high pressure system
750g FC003750 4 1500 200 — 300 2.5g — 75g
1500g FC0031500 3 2900 300 — 450 5.0g — 150g
High performance silica (20-30 µm, high resolution)
Size P/N Qty/PK CV (ml) Flow Rate (ml/min) Sample Loading
4g FCHP3004 14 5 19 ± 5 4mg — 0.4g
12g FCHP3012 14 17 30 ± 5 12mg — 1.2g
25g FCHP3025 10 34 35 ± 10 25mg — 2.5g
40g FCHP3040 10 57 40 ± 15 40mg — 4.0g
80g FCHP3080 6 120 60 ± 20 80mg — 8.0g
120g FCHP3120 6 190 85 ± 20 0.12g — 12g
240g FCHP3240 4 330 60 — 150 0.24g — 24g
330g FCHP3330 3 450 100 — 200 0.33g — 33g

 

Silica-based specialty phase columns

Luknova packs SuperSep™ C18, Cyano, Diol, Amine, SAX, and SCX functionalized-silica columns and high purity alumina columns for reversed-phase and normal phase separation based on polarity, charge, and acid and basic properties. Functionalized silica columns can be used up to more than 20 times.

 

Phase materials chemistry and polarity

Phase Chemistry Loading
SelectFlash™ Silica Si-OH NA
Alumina Acid Al2O3, pH=4.5 NA
Alumina Neutral Al2O3, pH=7.0 NA
Alumina Basic Al2O3, pH=9.5 NA
SuperBond™ Amine Si-(CH2)3-NH2 6.70%
SuperBond™ Diol Si-(CH2)3-O-CH2CH(OH)-CH2OH 8.00%
SuperBond™ Cyano Si-(CH2)3-CN 7.00%
SuperBond™ C18 Si-(CH2)17-CH3 17%
SuperBond™ SAX Si-(CH2)3-N+(CH3)3Cl- 8.40%
SuperBond™ SCX Si-(CH2)2-Ph-SO3H 11%

 

 Order Information of Phase Materials to Pack Columns

P/N Description   P/N Description
SG230400-05 SelectFlash™ silica, 50µm, 60Å, 500g/PK. LU025BM SuperBond™ Alumina Acid, 1kg/PK.
SG230400-25 SelectFlash™ silica, 50µm, 60Å, 25Kg/PK. LU026BM SuperBond™ Alumina Neutral, 1kg/PK.
SGFLASHAM-1 SelectBond™ Amine, 50µm, 60Å, 1kg/PK. LU027BM SuperBond™ Alumina Base, 1kg/PK.
SGFLASHC18-1 SelectBond™ C-18, 50µm, 60Å, 1kg/PK. LU029BM SuperBond™ Aminopropyl, 1kg/PK.
SGFLASHC4-1 SelectBond™ C-4, 50µm, 60Å, 1kg/PK. LU030BM SuperBond™ SAX, 1kg/PK.
SGFLASHC8-1 SelectBond™ C-8, 50µm, 60Å, 1kg/PK. LU031BM SuperBond™ Diethylamine, 1kg/PK.
SGFLASHCY-1 SelectBond™ Cyano, 50µm, 60Å, 1kg/PK. LU032BM SuperBond™ Diamine, 1kg/PK.
SGFLASHDL-1 SelectBond™ Diol, 50µm, 60Å, 1kg/PK. LU033BM SuperBond™ Carboxylic Acid, 1kg/PK.
SGFLASHSAX-1 SelectBond™ SAX, 50µm, 60Å, 1kg/PK. LU034BM SuperBond™ Benzenesulfonic Acid, 1kg/PK.
SGFLASHSCX-1 SelectBond™ SCX, 50µm, 60Å, 1kg/PK. LU035BM SuperBond™ Propylsulfonic Acid, 1kg/PK.
LU011BM SuperBond™ C18 Octadecyl endcapped, 1kg/PK. LU036BM SuperBond™ Triacetic Acid, 1kg/PK.
LU012BM SuperBond™ C18 Octadecyl unendcapped, 1kg/PK. LU037BM SuperBond™ Aminopropyl + C8, 1kg/PK.
LU013BM SuperBond™ C8 Octyl endcapped, 1kg/PK. LU038BM SuperBond™ SAX + C8, 1kg/PK.
LU014BM SuperBond™ C8 Octyl unendcapped, 1kg/PK. LU039BM SuperBond™ Carboxylic Acid + C8, 1kg/PK.
LU015BM SuperBond™ Phenyl endcapped, 1kg/PK. LU040BM SuperBond™ Propylsulfonic Acid+C8, 1kg/PK.
LU021BM SuperBond™ Diol, 1kg/PK. LU041BM SuperBond™ Benzensulfonic Acid+C8, 1kg/PK.
LU022BM SuperBond™ Cyanopropyl endcapped, 1kg/PK. LU042BM SuperBond™ Cyanopropyl + C8, 1kg/PK.
LU024BM SuperBond™ Florisil PR, 1kg/PK. LU059BM SuperBond™ Celite 545, 1kg/PK.

 

Order Information for silica-based specialty flash columns

Packing material, wt 5.5g 16.5g 34g 50g 100g 150g 300g 420g
Volume Equivalent to silica in wt 4g 12g 25g 40g 80g 120g 240g 330g
Qty 2/PK 1/PK 1/PK 1/PK 1/PK 1/PK 1/PK 1/PK
SuperBond C18 FR004-1 FR012-1 FR025-1 FR040-1 FR080-1 FR120-1 FR240-1 FR330-1
SuperBond Amine FAM004-1 FAM012-1 FAM025-1 FAM040-1 FAM080-1 FAM120-1 FAM240-1 FAM330-1
SuperBond Cyano FCY004-1 FCY012-1 FCY025-1 FAY040-1 FCY080-1 FCY120-1 FCY240-1 FCY330-1
SuperBond Diol FDL004-1 FDL012-1 FDL025-1 FAY040-1 FDL080-1 FDL120-1 FDL240-1 FDL330-1
SuperBond SAX FSA004-1 FSA012-1 FSA025-1 FAY040-1 FSA080-1 FSA120-1 FSA240-1 FSA330-1
SuperBond SCX FSC004-1 FSC012-1 FSC025-1 FAY040-1 FSC080-1 FSC120-1 FSC240-1 FSC330-1
Flow rate, mL/min 18±5 30±5 35±10 40±10 60±15 85±15 60 — 170 80 — 220

 

SuperSep Empty Flash Cartridge Housing

Luknova provides proprietary empty flash cartridges to meet client specific needs. A variety of process and approaches can be employed to achieve the leak-free column assembly, such as clamping the filled column securely to a ring stand when mount the sealing insert, align the perforated cap, and tighten the perforated cap onto the column body container. Luknova utilizes custom-made instrument to pack tight and leak-free flash columns. We also provide custom packing services with client media.

 

Order Information of Empty Flash Cartridge Housing

Size P/N Qty/PK CV(ml)   Size P/N Qty/PK CV(ml)  
4g FC003004-1 40 5 120g FC003120-1 8 190
FC003004-2 480 FC003120-2 64
12g FC003012-1 30 17 240g FC003240-1 4 330
FC003012-2 360 FC003240-2 32
25g FC003025-1 25 34 330g FC003330-1 4 450
FC003025-2 300 FC003330-2 32
40g FC003040-1 25 57 750g FC003750-1 4 1500
FC003040-2 300 1500g FC0031500-1 3 2900
80g FC003080-1 10 120 Note: Each column comes with a complete set of parts, including 1 cap, 1 sealing insert, 1 body, 1 top frit, and 1 inserted bottom frit.
FC003080-2 80

  

Order Information of Frits for Empty Flash Cartridge Housing

Size

Description

Qty/PK

P/N

4g

Top and bottom frits (20µm) for 4g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003004-7

12g

Top and bottom frits (20µm) for 12g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003012-7

25g

Top and bottom frits (20µm) for 25g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003025-7

40g

Top and bottom frits (20µm) for 40g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003040-7

80g

Top and bottom frits 20µm) for 80g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003080-7

120g

Top and bottom frits (20µm) for 120g cartridge housing

100 Sets (100 Top & 100 Bottom)

FC003120-7

240g

Top and bottom frits (20µm) for 240g cartridge housing

50 Sets (50 Top & 50 Bottom)

FC003240-7

330g

Top and bottom frits (20µm) for 330g cartridge housing

50 Sets (50 Top & 50 Bottom)

FC003330-7

750g

Top and bottom frits (20µm) for 750g cartridge housing

50 Sets (50 Top & 50 Bottom)

FC003750-7

1500g

Top and bottom frits (20µm) for 1500g cartridge housing

50 Sets (50 Top & 50 Bottom)

FC0031500-7

 

FlashMaster and dry load columns

Luknova SuperSep™ FLM columns are packed with Silica, Alumina (neutral, acid, basic), and C18, Cyano, Diol, Amine, SAX, and SCX functionalized-silica media. These columns are designed to be compatible with Biotage™ FlashMaster™ flash purification instruments.

 

Order Information for silica-based specialty flash columns

Silica wt 2g 5g 10g 15g 20g 25g 50g 70g
Entire Tube Volume 15ml 25ml 70ml 70ml 70ml 150ml 150ml 150ml
Qty 20/PK 20/PK 16/PK 16/PK 16/PK 8/PK 8/PK 8/PK
Silica FLMSC2 FLMSC5 FLMSC10 FLMSC15 FLMSC20 FLMSC25 FLMSC50 FLMSC70
Phase Volume Equivalent to Silica in Weight
2g 5g 10g 15g 20g 25g 50g 70g
Alumina Neutral FLMAN2 FLMAN5 FLMAN10 FLMAN15 FLMAN20 FLMAN25 FLMAN50 FLMAN70
Alumina Acid FLMAC2 FLMAC5 FLMAC10 FLMAC15 FLMAC20 FLMAC25 FLMAC50 FLMAC70
Alumina Basic FLMAB2 FLMAB5 FLMAB10 FLMAB15 FLMAB20 FLMAB25 FLMAB50 FLMAB70
SuperBond C18 FLMRP2 FLMRP5 FLMRP10 FLMRP15 FLMRP20 FLMRP25 FLMRP50 FLMRP70
SuperBond Amine FLMAM2 FLMAM5 FLMAM10 FLMAM15 FLMAM20 FLMAM25 FLMAM50 FLMAM70
SuperBond Cyano FLMCY2 FLMCY5 FLMCY10 FLMCY15 FLMCY20 FLMCY25 FLMCY50 FLMCY70
SuperBond Diol FLMDL2 FLMDL5 FLMDL10 FLMDL15 FLMDL20 FLMDL25 FLMDL50 FLMDL70
SuperBond SAX FLMSA2 FLMSA5 FLMSA10 FLMSA15 FLMSA20 FLMSA25 FLMSA50 FLMSA70
SuperBond SCX FLMSC2 FLMSC5 FLMSC10 FLMSC15 FLMSC20 FLMSC25 FLMSC50 FLMSC70

  

SuperSep Solid Load Cartridges (compatible with ISCO)

Luknova® SuperSep Solid Load Cartridges are used to improve the separation efficiency and compound purity for low-solubility sample purification by eliminating the impurities and minimizing the byproducts. For low-solubility sample, loading the empty cartridges with a slurry mixture of the dissolved low-solubility sample and supporting media. Prior to the cartridge loading, the vacuum vaporization of the solvent typically improves the purification efficiency. The dissolved sample can be loaded directly onto the top of the prepacked load cartridges packed with Silica, Alumina, C18, Celite, Cyano, Diol, Amine, SAX, and SCX.

 

 Order Information for silica-based specialty flash columns 

Size Description Qty P/N  
5g/15ml 5g/15ml SuperSep solid load cartridges, empty. 80 SPE05-80
960 SPE05-960
25g/75ml 25g/75ml SuperSep solid load cartridges, empty. 20 SPE25-20
240 SPE25-240
65g/150ml 65g/150ml SuperSep solid load cartridges, empty. 12 SPE65-12
260g/700ml 260g/750ml SuperSep solid load cartridges, empty. 6 SPE260-6

 

Packed Mass  /Tube Volume Silica Gel Celite C18
Qty P/N Qty P/N Qty P/N
2.5g/15ml 40 SPE05A2 40 SPE05CE2 40 SPE05R2
2.5g/15ml 960 SPE05A2-0 960 SPE05CE2-0 960 SPE05R2-0
5g/15ml 40 SPE05A5 40 SPE05CE5 40 SPE05R5
5g/15ml 960 SPE05A5-0 960 SPE05CE5-0 960 SPE05R5-0
12g/75ml 20 SPE25A12 20 SPE25CE12 20 SPE25R12
12g/75ml 240 SPE25A12-0 240 SPE25CE12-0 240 SPE25R12-0
25g/75ml 20 SPE25A25 20 SPE25CE25 20 SPE25R25
25g/75ml 240 SPE25A25-0 240 SPE25CE25-0 240 SPE25R25-0
32g/150ml 12 SPE65A32 12 SPE65CE32 12 SPE65R32
65g/150ml 12 SPE65A65 12 SPE65CE65 12 SPE65R65
125g/750ml 4 SPE260A125 4 SPE260CE125 4 SPE260R125
260g/750ml 4 SPE260A260 4 SPE260CE260 4 SPE260R260

 

Adaptor and Accessories

For Biotage Horizon, SP1, SP4, and FlashMaster systems, less expensive line connection as shown below (following left side) is recommended by using Luer fittings and lines. The top connection line which comes from the pump outlet connects to the column inlet via a red-black adapter (P/N: LK1687). The column outlet is connected with adaptor bottom section (P/N: LK1689) to the UV detector. The Luer Lock Adapters are used to connect column either inlet, outlet, or both as shown below (right side) when needed, such as for stacking multiple columns and fitting into used or refurbished purification instruments.

  

P/N Description  
LK1687 Biotage System Adaptor, top (inlet) section,  1/EA.
LK1688 Biotage System Adaptor, 1 set/EA.
LK1689 Biotage System Adaptor, bottom (outlet) section,  1/EA.
LK1690 Luer Lock Adapter, Natural Polypropylene. Transparent, 50/PK.
LK1691 Luer Lock Adapter, White Nylon, 50/PK.
LK1692 Plastic insertion rod for 5g dry loading columns,1/EA.  
LK1693 Plastic insertion rod for 25g dry loading columns,1/EA.
LK1700 Plastic insertion rod for 4g empty flash columns,1/EA.
LK1702 Plastic insertion rod for 12g/25g empty flash columns,1/EA.
LK1704 Plastic insertion rod for 40g/80g empty flash columns,1/EA.
LK1706 Plastic insertion rod for 120g empty flash columns,1/EA.
LK1708 Plastic insertion rod for 240g/330 empty flash columns,1/EA.

 

Features and Advantages

  • Ultra pure silica gel with narrow particle size distribution.
  • Neutral silica gel (pH 6.8-7.2) enables the compounds remain intact on columns.
  • Innovative and patented column design allows easy sample recovery, you can open the column to recover the sample.
  • Convenient to conduct packing material loading, reloading and dry loading.
  • Advanced mechanical packing brings uniform column packing density and guarantees column performance consistency.
  • Standard silica at particle size 40-60 µm (averaged 50 µm) is very good for typical and regular purification.
  • High performance silica at particle size 20-30 µm (averaged 25 µm) has higher resolution and loading capacity.

 

Flash Column Technical Specs

Sizes 4g, 12g, 25g, 40g, 80g, 120g, 240g, 330g, 750g, and 1500g
Tube Material Inert medical-grade polypropylene (PP)
Frit Material Inert polyethylene (PE)
Pressure Range 0-200 psi / 14 bar (100 psi / 7 bar for 750 and 1500g)
Media 25 micron and 50 micron silica gel and silica-bounded specialty phases
Resolution

Minimum 7000 N/m (plates per meter) and typical 10 000 N/m for 25 micron silica

Minimum 3000 N/m (plates per meter) for 50 micron silica.

Compatibility Universal Luer connection at top inlet and needle shape at outlet
Flash Column Phase Selection Guide

 

 

Phase materials chemistry and polarity

  Phase Chemistry Loading
SuperBond C18 Si-(CH2)17-CH3 17%
SuperBond Amine Si-(CH2)3-NH2 6.70%
SuperBond Cyano Si-(CH2)3-CN 7.00%
SuperBond Diol Si-(CH2)3-O-CH2CH(OH)-CH2OH 8.00%
SuperBond SAX Si-(CH2)3-N+(CH3)3Cl- 8.40%
SuperBond SCX Si-(CH2)2-Ph-SO3H 11%
Alumina Acid Al2O3, pH=4.5 NA
Alumina Neutral Al2O3, pH=7.0 NA
Alumina Basic Al2O3, pH=9.5 NA

 

Typical performance of Luknova flash columns on ISCO system

The high purity silica gel with narrow particle size distribution and narrow pH range and special mechanical packing technology enable significant advantages over leading competitors in purification efficiency, resolution, and column reproducibility.  A representative purification chromatography on ISCO system is shown below :

A typical plot of purification and separation performance using Luknova supersep™ silica flash column

 

 

Performance comparison of Luknova SuperSep™ standard and HP with competitor 12g columns

The comparison of Luknova SuperSep standard (averaged 50 micron particle size) and high performance (HP) (averaged 25 micron particle size) with those from leading competitors are shown below. Luknova standard column showed excellent performance as shown sharper peaks and reduced peaks overlapping.

 

 

 A comparison of Luknova supersep™ 12g silica flash columns with those from competitors.

 

Luknova flash column purification delivered a 96.96% product purity

Sample Information:

Undisclosed real sample. A mixture of tertiary alcohols from reactions of boronic acid coupling to an aryl bromide and a second reaction of sonogashira reaction of an acetylene with an aryl bromide. All the products and impurities from the reactions contain alcohols.

 

Fraction Purity:

A 96.96% reported purity of the fraction based on Mass Spectroscopy analysis.

 

Flash Column

Luknova SuperSep™ standard 120gram silica gel flash column.

 

SuperSep™ C18 Columns Experimental Tips

 

System Preparation: C18 columns operate under reversed phase conditions (i.e., 100% Water ? 100% Acetonitrile). When ready to switch from normal phase to reversed phase purification, make sure (i) air purge solvent A and B lines, (ii) flush solvent A and B lines with high purity acetonitrile, methanol, or ethanol, and (iii) flush solvent A line with aqueous solvent thoroughly.

C18 Column Preconditioning: Use six to seven column volumes of 1/1 water/acetonitrile (or water/methanol) mixture to flush the C18 column prior to first and immediate use. In an alternative way, pre-equilibrate with twice column volume (CV) of 100% acetonitrile and store for 1hr prior to use.

End of the Run Care and Storage: At the end of the separation run, wash the column with four column volumes 100% acetonitrile or organic solvent B. It is recommended that only after the wash with 100% organic solvent, the purification can be returned to the condition of the start of the run and start the next run. At the end of the run, flush the column with four column volumes of 80% organic solvent + 20% water and capped wet to store for future use.

 

 

Flash Columns Application in Selected Publications

  1. Further insight into the asymmetric vinylogous Mukaiyama aldol reaction (VMAR); application to the synthesis of the C27–C45 segment of lagunamide A, Brent A. Banasik, Lee Wang, Arielle Kanner, B. Mikael Bergdahl, Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA, Tetrahedron, Volume 72, Issue 19, 12 May 2016, Pages 2481–2490.  Article link.
  2. 2,2,2-Trifluoroethyl Oxalates in the One-Pot Parallel Synthesis of Hindered Aliphatic Oxamides†,Andrey V. Bogolubsky, Yurii S. Moroz, Pavel K. Mykhailiuk, Sergey E. Pipko, Alexander V. Grishchenko, Anton V. Zhemera, Anzhelika I. Konovets, Roman A. Doroschuk, Yurii V. Dmytriv, Olga A. Zaporozhets and Andrey Tolmachev, European Journal of Organic Chemistry, Volume 2016, Issue 12, pages 2120–2130, April 2016.   Article link.
  3. Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s), Pushkar M. Kulkarni‡, Abhijit R. Kulkarni‡, Anisha Korde‡∥, Ritesh B. Tichkule∥#, Robert B. Laprairie$, Eileen M. Denovan-Wright$, Han Zhou∥#, David R. Janero‡∥, Nikolai Zvonok∥, Alexandros Makriyannis‡∥#, Maria G. Cascio§, Roger G. Pertwee§, and Ganesh A. Thakur*‡; ‡Department of Pharmaceutical Sciences, Bouvé College of Pharmacy, ∥Center for Drug Discovery, and #Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States; $ Department of Pharmacology, Dalhousie University, Halifax NS Canada B3H 4R2; School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland;  J. Med. Chem., 2016, 59 (1), pp 44–60.   Article link.

  4. Separation of [99mTc]pertechnetate and molybdate using polyethylene glycol coated C18 and C30 resins, J.D. Anderssona, , , J.S. Wilsonb, J.A. Romaniuka, A.J.B. McEwanb, D.N. Abramsa, S.A. McQuarriea, K. Gagnona; a- University of Alberta, Medical Isotope and Cyclotron Facility, Edmonton, AB, Canada; b- Edmonton PET Centre, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada; Applied Radiation and Isotopes, Volume 110, April 2016, Pages 193–199.  Article link.

  5. Synthesis of many different types of organic small molecules using one automated process, Junqi Li*, Steven G. Ballmer*, Eric P. Gillis, Seiko Fujii, Michael J. Schmidt, Andrea M. E. Palazzolo, Jonathan W. Lehmann, Greg F. Morehouse, Martin D. Burke†; Howard Hughes Medical Institute (HHMI), Department of chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Science  13 Mar 2015:Vol. 347, Issue 6227, pp. 1221-1226.  Article link and  Supplementary Materials link in PDF (free Document in English).
  6. One-Pot Parallel Synthesis of Alkyl Sulfides, Sulfoxides, and Sulfones, Andrey V. Bogolubsky†, Yurii S. Moroz*†‡, Pavel K. Mykhailiuk*†§, Eugeniy N. Ostapchuk†‡, Alexander V. Rudnichenko†, Yurii V. Dmytriv†, Anna N. Bondar§, Olga A. Zaporozhets§, Sergey E. Pipko‡, Roman A. Doroschuk§, Liudmyla N. Babichenko†‡, Anzhelika I. Konovets†∥, and Andrey Tolmachev†‡; Enamine, Ltd., 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; ChemBioCenter, Kyiv National Taras Shevchenko University, 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; § Department of Chemistry, Kyiv National Taras Shevchenko University, 64 Volodymyrska Street, Kyiv, 01601, Ukraine; The Institute of High Technologies, Kyiv National Taras Shevchenko University, 4 Glushkov Street, Building 5, Kyiv, 03187, Ukraine. ACS Comb. Sci., 2015, 17 (6), pp 348–354.  Article link.

  7. 2,2,2-Trifluoroethyl Chlorooxoacetate—Universal Reagent for One-Pot Parallel Synthesis of N1-Aryl-N2-alkyl-Substituted Oxamides, Andrey V. Bogolubsky†, Yurii S. Moroz*†‡, Pavel K. Mykhailiuk*†§, Sergey E. Pipko‡, Anton V. Zhemera†, Anzhelika I. Konovets†∥, Olena O. Stepaniuk†$, Inna S. Myronchuk†$, Yurii V. Dmytriv†, Roman A. Doroschuk§, Olga A. Zaporozhets§, and Andrey Tolmachev†‡; Enamine, Ltd., 78 Chervonotkatska Street, Kyiv, 02094, Ukraine; ChemBioCenter, Kyiv National Taras Shevchenko University, 61 Chervonotkatska Street, Kyiv, 02094, Ukraine; § Department of Chemistry, Kyiv National Taras Shevchenko University, 64 Volodymyrska Street, Kyiv, 01601, Ukraine; The Institute of High Technologies, Kyiv National Taras Shevchenko University, 4 Glushkov Street, Building 5, Kyiv, 03187, Ukraine; $ National Technical University of Ukraine “Kyiv Politechnic Institute”, 37 Peremohy Avenue, Kyiv, 03056, Ukraine; ACS Comb. Sci., 2015, 17 (10), pp 615–622.  Article link.

  8. Discovery of a Highly Tumor-Selective Organometallic Ruthenium(II)–Arene Complex, Catherine M. Clavel†, Emilia Păunescu†, Patrycja Nowak-Sliwinska†, Arjan W. Griffioen‡, Rosario Scopelliti†, and Paul J. Dyson*†; Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland; Angiogenesis Laboratory, Department of Medical Oncology, VUMC Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands; J. Med. Chem., 2014, 57 (8), pp 3546–3558.  Article link.

  9. Structure–activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis, Anja Meissnera, Helena I. Boshoffb, Mahalakshmi Vasana, Benjamin P. Duckwortha, Clifton E. Barry IIIb, Courtney C. Aldricha, , a Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA; b Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. Bioorganic & Medicinal Chemistry, Volume 21, Issue 21, 1 November 2013, Pages 6385–6397.  Article link.

  10. Non-Nucleoside Inhibitors of BasE, an Adenylating Enzyme in the Siderophore Biosynthetic Pathway of the Opportunistic Pathogen Acinetobacter baumanniiJoão Neres†, Curtis A. Engelhart†‡, Eric J. Drake§, Daniel J. Wilson†, Peng Fu†, Helena I. Boshoff∥, Clifton E. Barry3rd∥, Andrew M. Gulick§, and Courtney C. Aldrich*†; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, United States; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States; § Hauptman-Woodward Institute and Department of Structural Biology, University at Buffalo, Buffalo, New York 14203-1102, United States; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, United States; J. Med. Chem., 2013, 56 (6), pp 2385–2405.  Article link.

  11. Transformation of Pro-Leu-Gly-NH2 Peptidomimetic Positive Allosteric Modulators of the Dopamine D2 Receptor into Negative Modulators, Swapna Bhagwanth†, Satyendra Mishra†, Ritesh Daya‡, Jordan Mah‡, Ram K. Mishra‡, and Rodney L. Johnson*; Department of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, United States; Department of Psychiatry and Behavioral Neurosciences, McMaster University, 1200 Main Street W, Hamilton, Ontario L8N 3Z5, Canada.  ACS Chem. Neurosci., 2012, 3 (4), pp 274–284.  Article link.

  12. Application of chemoenzymatic hydrolysis in the synthesis of 2-monoacylglycerols, Kyle M. Whitten, Alexandros Makriyannis, Subramanian K. Vadivel; Center for Drug Discovery, 116 Mugar Hall, 360 Huntington Avenue, Northeastern University, Boston, MA 02115, Unites States. Tetrahedron, Volume 68, Issues 27–28, 8 July 2012, Pages 5422–5428.  Article link.

  13. Coupling flash liquid chromatography with mass spectrometry for enrichment and isolation of milk oligosaccharides for functional studies, John S. Struma, Danielle Aldredgea, Daniela Barileb, Carlito B. Lebrillaa,c; a Department of Chemistry, University of California, Davis, Davis, CA 95616, USA; b Foods for Health Institute, Department of Food Science and Technology, University of California, Davis, Davis, CA 95616, USA; c Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA 95616, USA. Analytical Biochemistry, Volume 424, Issue 2, 15 May 2012, Pages 87–96.  Article link.
  14. Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective against Mycobacterium tuberculosisAmol Gupte†, Helena I. Boshoff‡, Daniel J. Wilson†, João Neres†, Nicholas P. Labello†, Ravindranadh V. Somu†, Chengguo Xing§, Clifton E. BarryIII‡ and Courtney C. Aldrich*†; Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, J. Med. Chem., 2008, 51 (23), pp 7495–7507.   Article link. 

 

 

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